Mayo clinic ophthalmology retina update and case conference. Inflammation is the bodys natural response to tissue damage, germs, or toxins. In patients with intermediate uveitis 30 eyes, intraocular lensrelated uveitis 7 eyes, and pseudophakic uveitis 1 eye, ubm revealed changes in the iris, ciliary body and adjacent structures. Foster is the leader in the aggressive medical management of ocular inflammatory diseases, and the book reflects 25 years experience in the worlds busiest uveitis clinic. Iu accounts for up to 15% of uveitis cases in adults, with higher percentages reported at tertiary referral centers, and accounts for up to 28% of uveitis. The main cause of intermediate uveitis is not identified but. Intermediate uveitis is characterized by vitreal inflammation with associated inflammation of the vitreous base and peripheral anterior retina and choroid.
Intermediate uveitis pars planitis krishna eye centre. Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the outer fibrous layer composed of the sclera and cornea. The term intermediate uveitis iu was introduced by the international uveitis study group iusg to define an idiopathic inflammatory syndrome, mainly involving the anterior vitreous, the peripheral retina, and the ciliary body to replace previously used terms such as posterior cyclitis, hyalitis, vitritis, and basal uveoretinitis 8. Request pdf intermediate uveitis intermediate uveitis iu is characterized by ocular inflammation involving mainly the vitreous. The narrative is easy to understand and the visuals are delightful. Uveitis information group what is intermediate uveitis. Uveitis can be further subdivided into anterior, intermediate, posterior, and panuveitis based on the primary anatomical location of the inflammation in the eye. Historically, uveitis is a term used to describe inflammatory processes of the portion of the eye known as the uvea, which is composed of the iris, ciliary body, and the choroid.
This middle part, the pars plana, is that part of the eye between the ciliary body and the retina. Clinical course patients with intermediate uveitis visual outcomes often favorable mean visual acuity after 10 years of follow up2030 75% maintained va or 2040 or better one third maintained va normal without treatment 15. Patients with uveitis and ms are significantly older and more likely to be women than patients with idiopathic intermediate uveitis. Pars planitis nord national organization for rare disorders. Whitcup provide a cohesive and integrated discussion of the topic, covering everything from the role of surgery to aids to anterior uveitis and more.
Uveitis what it is, what causes it, and how to treat it. It incorporates pars planitis, posterior cyclitis, and hyalitis. Molly presents the disease in an informative and nonfrightening way. Snow banking is generally described in intermediate uveitis due to autoimmune etiology and has not been described frequently in. Systemic diseases associated with intermediate uveitis. Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, sn. In a retrospective, populationbased cohort study the incidence of pars planitis was. Associations of the disease with such entities as ms, sarcoidosis, or inflammatory bowel disease suggest an autoimmune component in at least a subset of patients. Intermediate uveitis was first described in the literature as chronic cyclitis by fuchs in 1908. Anterior uveitis is not associated with snowballs, typically found in intermediate uveitis, or chorioretinal inflammation. Intermediate uveitis iu is a chronic, relapsing disease of insidious onset.
If all three categories are involved, the term panuveitis is used. It may be found as an isolated and idiopathic condition or in association with systemic disorders such. Iusg intermediate uveitis international uveitis study group. In intermediate uveitis, cells collect and float in the vitreous gel in the back of the eye. Immunopathogenic background of pars planitis springerlink. The anterior segment, retina, and the optic disc may also be involved. Intermediate uveitis intermediate uveitis iu is described as inflammation in the anterior vitreous, pars plana and the peripheral retina the diagnostic term pars planitis should be used only for that subset of iu where there is snow bank or snowball formation occurring in the absence of an associated infection or systemic disease 7.
This new edition even includes full color throughout with 400 photographs and illustrations. This comprehensive volume presents both immunologic fundamentals as they relate to uveitis and the practical approach to the treatment of these diseases. According to the standardization of uveitis nomenclature working group, the primary site of inflammation is the vitreous and such entities as pars planitis, posterior cyclitis, and hyalitis are encompassed. The term intermediate refers to the anatomic location of the inflammatory reaction, the middle of the eye. Intermediate uveitis is a form of uveitis that affects the area in the middle of the uvea the pars plana. Uveitis is an ophthalmic emergency and requires a thorough examination by an ophthalmologist or optometrist. Intermediate uveitis is a category of uveitis based on an anatomical classification system that can include diseases of various etiology and clinical manifestations. Uveitis is the comprehensive reference you need for a balanced approach to basic science and clinical application. Epidemiology and etiology iu most often occurs in children and young adults. Out of 1273 uveitis cases, anterior uveitis was the most common type 39. Although pars planitis is generally benign, there can be significant vision loss in extreme cases. Intermediate uveitis includes posterior cyclitis, pars planitis, and hyalitis. Epidemiology intermediate uveitis accounts for approximately 10% of uveitis cases in a referral practice. Primary sites of inflammation include the vitreous of which other such entities as pars planitis.
The illustration on the right graphically shows the clinical features of pars planitis snowballs. The purpose of this study was to identify the causes, clinical features, and outcomes of intermediate uveitis, posterior uveitis, and panuveitis in patients managed in a mid. It has been identified to be associated with certain diseases as multiple sclerosis, sarcoidosis, or. Intermediate uveitis an overview sciencedirect topics. Intermediate uveitis is also sometimes called pars planitis.
The part of the eye affected is the peripheral part of the inner eye in between the posterior and anterior parts see diagram below the older terms pars planitis and cyclitis are often used to describe this type of uveitis. Posterior uveitis is less common 1530% of cases of uveitis, followed by intermediate uveitis around 15% of cases of uveitis. Characteristic mobile, globular, yellowwhite snowballs ants eggs can be. Uveitis experts standardized the nomenclature for uveitis sun in 2005. The inflammation is most marked in the middle part of the uveal tract of the eye. Posterior uveitis refers to inflammation of the retina or choroid.
Anterior uveitis accounts for the majority of uveitis cases 7090%. This book is distributed under the terms of the creative commons. Intermediate uveitis accounts for approximately 48% of cases of uveitis in a referral practice. Intermediate uveitis iu is the subset of uveitis where the major site of. Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Clinical methods in uveitis, st louis, 1968, mosbyyear book, inc, pp 204209. According to the standardization of uveitis nomenclature sun working group criteria, iu is defined as an intraocular inflammation mainly focused on the vitreous and peripheral retina. Billal hossain national institute of ophthalmology and hospital. In tuberculosisendemic countries like india, tuberculosis is an important etiologic cause of intermediate uveitis. Intermediate uveitis definition of intermediate uveitis.
Intermediate uveitis refers to inflammation localized to the vitreous and peripheral retina. It produces swelling, redness, heat, and destroys tissues as certain white blood cells rush to the affected part of the body to contain or eliminate the insult. This is the inflammation of the middle part of the uvea, namely the pars plana or area between the ciliary body and retina. In the standardization of uveitis nomenclature sun working groups international workshop for reporting clinical data the consensus reached was that the term iu should be used for that subset of uveitis where the vitreous is the major site of the inflammation and if there.
Intermediate uveitis involves the middle layer of the eye, which includes the vitreous. Uveitis with ms typically presents with intermediate uveitis. Intermediate uveitis refers to inflammation just behind the iris, sometimes known as pars planitis. Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The paper highlights two important clinical points. The term, intermediate uveitis is used to describe the location of the inflammation in the eye. Intermediate uveitis iu is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. Uveitis is caused by inflammatory responses inside the eye.
Uveitis can also lead to things like cataracts, glaucoma, damage to the optic nerve, and detachment of the retina, a thin tissue that lines the back of your eye. With contributions from 60 international specialists, this new. The uvea consists of the middle layer of pigmented vascular structures of the eye and includes the iris, ciliary body, and choroid. Intermediate uveitis is a chronic condition in which the signs of inflammation are most pronounced in the vitreous. Intermediate uveitis is the second most common form of uveitis and both the eyes are usually affected however, those that are more predisposed to varying types of infection and immunologic conditions may be at a higher risk for developing intermediate uveitis. Intermediate uveitis also known as pars planitis or cyclitis this is a chronic uveitis of unknown cause. Intermediate uveitis, posterior uveitis, and panuveitis in the midatlantic usa stephanie b engelhard, vandan patel, ashvini k reddy department of ophthalmology, university of virginia, charlottesville, va, usa background. It is characterized by vitreal inflammatory aggregates snowballs, and whitish. Intermediate uveitis iu refers to ocular inflammation that localizes primarily to the vitreous and peripheral retina. Intermediate uveitis refers to inflammation localized to the vitreous. Intermediate uveitis is generally believed to be autoimmune in nature, and snow banking is an important clinical sign of intermediate uveitis. According to these criteria, intermediate uveitis is defined as an intraocular inflammation mainly focused on the vitreous and peripheral retina 3, 4. Young age as a risk factor for complicated course and visual outcome in intermediate uveitis in children.